L-Methylfolate

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Methylation controls multiple biochemical pathways in your body.

Your genetics, heart health, hormones, sleep, stress, mood, and detoxification depend on healthy methylation.

Where does your body get the methyl groups needed to carry out methylation? Primarily from folates that come from food and intestinal microbes. Food folates must be first converted into an active form before your body can use them.

Your MTHFR enzyme converts food folates into the active form of folate, methylfolate. This bioavailable form is also known as L-methylfolate. The true biochemical name is L-5-methyltetrahydrofolate (L-5-MTHF).

Over 50 percent of the population is thought to have a genetic mutation in their MTHFR gene. Thus, they may not be achieving adequate methylfolate levels from food alone.

Because L-5-MTHF bypasses the MTHFR enzyme, it can provide methylation support for those with MTHFR polymorphisms.

Folate (as bioavailable L-methylfolate) is:

  • Easily absorbed and used by cells The predominant form of folate in circulation The only form of folate that can cross the blood-brain barrier Essential for methylation, DNA expression, homocysteine metabolism, and nervous system function

Seeking Health’s L-methylfolate contains 1,700 mcg DFE of methylfolate in the bioavailable form of L-5-methyltetrahydrofolate (L-5-MTHF).

The bioactive form of L-methylfolate (L-5-MTHF) is well-utilized in the methylation cycle. It is often the preferred form for those with methylation, homocysteine, or MTHFR gene mutation concerns.

Mutations in your MTHFR gene can lead to reduced L-methylfolate production and a less functional methylation cycle. Challenges in the methylation cycle are associated with an increased risk for cardiovascular and mood issues, birth defects, and infertility concerns.

Mutations in this gene can also slow your body’s ability to convert folate into its active forms. Thus, a large majority of people may benefit from consuming an L-methylfolate dietary supplement.

The most direct way to support methylation and MTHFR genetic mutations is with L-methylfolate (L-5-MTHF).

Supplementing with bioavailable L-methylfolate supports:

  • Healthy methylation Positive mood Healthy homocysteine levels Nervous system function and development Prevention of neural tube defects during pregnancy Healthy energy production Normal cognitive, memory, and brain function

Get ready for your methylation cycle to fire on all cylinders with Seeking Health’s L-methylfolate!

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Methylation controls multiple biochemical pathways in your body.

Your genetics, heart health, hormones, sleep, stress, mood, and detoxification depend on healthy methylation.

Where does your body get the methyl groups needed to carry out methylation? Primarily from folates that come from food and intestinal microbes. Food folates must be first converted into an active form before your body can use them.

Your MTHFR enzyme converts food folates into the active form of folate, methylfolate. This bioavailable form is also known as L-methylfolate. The true biochemical name is L-5-methyltetrahydrofolate (L-5-MTHF).

Over 50 percent of the population is thought to have a genetic mutation in their MTHFR gene. Thus, they may not be achieving adequate methylfolate levels from food alone.

Because L-5-MTHF bypasses the MTHFR enzyme, it can provide methylation support for those with MTHFR polymorphisms.

Folate (as bioavailable L-methylfolate) is:

  • Easily absorbed and used by cells The predominant form of folate in circulation The only form of folate that can cross the blood-brain barrier Essential for methylation, DNA expression, homocysteine metabolism, and nervous system function

Seeking Health’s L-methylfolate contains 1,700 mcg DFE of methylfolate in the bioavailable form of L-5-methyltetrahydrofolate (L-5-MTHF).

The bioactive form of L-methylfolate (L-5-MTHF) is well-utilized in the methylation cycle. It is often the preferred form for those with methylation, homocysteine, or MTHFR gene mutation concerns.

Mutations in your MTHFR gene can lead to reduced L-methylfolate production and a less functional methylation cycle. Challenges in the methylation cycle are associated with an increased risk for cardiovascular and mood issues, birth defects, and infertility concerns.

Mutations in this gene can also slow your body’s ability to convert folate into its active forms. Thus, a large majority of people may benefit from consuming an L-methylfolate dietary supplement.

The most direct way to support methylation and MTHFR genetic mutations is with L-methylfolate (L-5-MTHF).

Supplementing with bioavailable L-methylfolate supports:

  • Healthy methylation Positive mood Healthy homocysteine levels Nervous system function and development Prevention of neural tube defects during pregnancy Healthy energy production Normal cognitive, memory, and brain function

Get ready for your methylation cycle to fire on all cylinders with Seeking Health’s L-methylfolate!

Methylation controls multiple biochemical pathways in your body.

Your genetics, heart health, hormones, sleep, stress, mood, and detoxification depend on healthy methylation.

Where does your body get the methyl groups needed to carry out methylation? Primarily from folates that come from food and intestinal microbes. Food folates must be first converted into an active form before your body can use them.

Your MTHFR enzyme converts food folates into the active form of folate, methylfolate. This bioavailable form is also known as L-methylfolate. The true biochemical name is L-5-methyltetrahydrofolate (L-5-MTHF).

Over 50 percent of the population is thought to have a genetic mutation in their MTHFR gene. Thus, they may not be achieving adequate methylfolate levels from food alone.

Because L-5-MTHF bypasses the MTHFR enzyme, it can provide methylation support for those with MTHFR polymorphisms.

Folate (as bioavailable L-methylfolate) is:

  • Easily absorbed and used by cells The predominant form of folate in circulation The only form of folate that can cross the blood-brain barrier Essential for methylation, DNA expression, homocysteine metabolism, and nervous system function

Seeking Health’s L-methylfolate contains 1,700 mcg DFE of methylfolate in the bioavailable form of L-5-methyltetrahydrofolate (L-5-MTHF).

The bioactive form of L-methylfolate (L-5-MTHF) is well-utilized in the methylation cycle. It is often the preferred form for those with methylation, homocysteine, or MTHFR gene mutation concerns.

Mutations in your MTHFR gene can lead to reduced L-methylfolate production and a less functional methylation cycle. Challenges in the methylation cycle are associated with an increased risk for cardiovascular and mood issues, birth defects, and infertility concerns.

Mutations in this gene can also slow your body’s ability to convert folate into its active forms. Thus, a large majority of people may benefit from consuming an L-methylfolate dietary supplement.

The most direct way to support methylation and MTHFR genetic mutations is with L-methylfolate (L-5-MTHF).

Supplementing with bioavailable L-methylfolate supports:

  • Healthy methylation Positive mood Healthy homocysteine levels Nervous system function and development Prevention of neural tube defects during pregnancy Healthy energy production Normal cognitive, memory, and brain function

Get ready for your methylation cycle to fire on all cylinders with Seeking Health’s L-methylfolate!

Key Ingredients In L-Methylfolate

  • L-5-MTHF: A superior form of L-methylfolate that readily donates its methyl groups. It aids conversion of the amino acid homocysteine into methionine and supports your entire methylation cycle.†

Why L-Methylfolate Works

Folate plays critical roles in methylation. By donating its methyl groups, folate regulates DNA expression and much more. Without sufficient bioavailable folate, your cells cannot effectively express your genes.†

The MTHFR gene converts food folates into methyl folates. However, MTHFR variations and environmental or lifestyle stress can slow this gene down. If the MTHFR gene is slowed, MTHFR enzyme function is also slowed. The result can be a debilitating folate deficiency.

The artificial version of folate, folic acid, is often prescribed to folate-deficient individuals. Supplementation with L-methylfolate may be more effective than folic acid supplementation at increasing blood folate levels.†

Folic acid is never included in any of our Seeking Health dietary supplements. This artificial version of folate is not well-utilized by the body and can produce adverse effects. Folic acid must go through several enzymatic steps before it is converted into usable methylfolate. Its inefficient chemical structure may even slow down your SLC191A, DHFR, and MTHFR genes to the point of folate deficiency! Folic acid can also block usable folate from entering your cells, further contributing to folate deficiency.†

By supplementing with the natural form of folate as L-5-MTHF, you bypass the MTHFR enzyme. The methylated form, L-5-methylfolate (L-5-MTHF), requires no additional metabolic steps to be used by the body. This is why it is often the preferred choice for those with folate absorption or metabolic defects.†

L-methylfolate also supports the production of important mood neurotransmitters. These include dopamine, serotonin, melatonin, epinephrine, and norepinephrine. This is how supplementation with L-5-MTHF can help to support a healthy mood.†

Seeking Heath’s L-methylfolate provides a pure, non-racemic form of L-methylfolate. Each easy-to-take capsule offers a potent dose of 1,700 mcg DFE of folate as Quatrefolic® (6S)-5-methyltetrahydrofolate, glucosamine salt. This superior form supports healthy methylation, mood, and more.†

Because folate needs B12 to support proper methylation, be sure to pair L-methylfolate with a bioactive form of B12, such as Active B12 1000.†

Now you can go about your day with confidence, knowing your methylation cycle is firing on all cylinders with L-methylfolate!†

 

Suggested Use

As needed, take 1 capsule with or without food. Do not take within 5 hours of bedtime as it may interfere with sleep. Use as directed by your healthcare professional.

Warnings

Consult with your healthcare professional prior to use. Do not use if inner tamper seal is damaged. †